Inducible Glutamate Oxaloacetate Transaminase as a Therapeutic Target Against Ischemic Stroke
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منابع مشابه
Effects of Vitamin B6 on the Brain Glutamate Pyrovate Transaminase and Glutamate Oxaloacetate Transaminase in Young and Old Rats
Excessive amounts of extracellular glutamate in brain are excitotoxic and lead to neuronal death. Glutamate pyrovate transamiase (GPT) and glutamate oxaloacetate transaminase (GOT) catalyze transamination of glutamate to alpha ketoglutarate. Because vitamin B6 is essential for the enzymes activities, this study was undertaken to examine the effect of vitamin B6 on age related changes of this en...
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Difluoro-oxaloacetate interacts with the aldimine form of aspartate transaminase to give a complex, the dissociation constant ofwhich has been determined spectrophotometrically and by 19F n.m.r. (nuclear magnetic resonance). The 19F n.m.r. line-width-pH and chemical-shift-pH profiles of difluoro-oxaloacetate in the presence of the aldimine form of the enzyme both show inflexion points in the pH...
متن کاملDetermination of the Chromosomal Location of a Glutamate Oxaloacetate Transaminase Structural Gene Using Triticum-agropyron Translocations1
The glutamate oxaloacetate transaminase (GOT) zymogram phenotypes of a series of 15 translocation lines, a chromosome addition line and a chromosome substitution line were determined. In each of the translocation lines a segment of the long arm of Triticum aestivum chromosome 3D has been replaced by a portion of an Agropyron elongatum homoeologue. Evidence was obtained that the products of the ...
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Apoptosis is a physiological cell death that occurs under normal conditions in major biological processes, including the removal of old, damaged, extra, or harmful cells. It plays an important role in natural evolution, tissue homeostasis, removal of cells damaged or infected by viruses, and removal of immune cells activated against self-antigens. The purpose of this review was to examine the r...
متن کاملThe intracellular distribution, latency and electrophoretic mobility of L-glutamate-oxaloacetate transaminase from rat liver.
Richardson, E. M., Bulaschenko, H. & Dohan, F. C. (1958). J. clin. Endocrin. 18, 666. Richardson, E. M., Touchstone, J. C., Dohan, F. C., Bulaschenko, H., Landolt, I. & Applin, W. (1955). J. clin. Invest. 34, 285. Rimini, E. (1901). Gazz. chim. ital. 31, II, 84. Romani, J. D. (1956a). C.R. Soc. Biol., Paris, 150, 644. Romani, J. D. (1956b). C.R. Soc. Biol., Paris, 150, 887. Romani, J. D. & Able...
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ژورنال
عنوان ژورنال: Antioxidants & Redox Signaling
سال: 2015
ISSN: 1523-0864,1557-7716
DOI: 10.1089/ars.2014.6106